College Football Picks Week 4: Top 25 Odds, Box Score Predictions, Rankings, Schedule

Joe TanseySeptember 16, 2024

College Football Picks Week 4: Top 25 Odds, Box Score Predictions, Rankings, Schedule

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    NASHVILLE, TENNESSEE - SEPTEMBER 14: Dont'e Thornton Jr. #1 of the Tennessee Volunteers runs away from Nick Cuva #36 of the Kent State Golden Flashes during the first half at Neyland Stadium on September 14, 2024 in Knoxville, Tennessee. (Photo by Brandon Sumrall/Getty Images)
    Brandon Sumrall/Getty Images

    The new normal in the SEC will be front and center in Week 4 of the college football season.

    The Oklahoma Sooners will host their first-ever SEC game on Saturday night against the Tennessee Volunteers.

    Tennessee comes into Norman off one of the fastest starts in the FBS, and its offense should give Oklahoma a good feel for how it stacks up in its new conference.

    Tennessee-Oklahoma will not decide the top team in the SEC, but it will help sort out the second tier of programs beneath the Georgia Bulldogs and Texas Longhorns.

    The Big 12 will begin an important two-week sorting-out process on Saturday, when the Utah Utes visit the Oklahoma State Cowboys.

    Three Big 12 teams reside in the Top 15 of the AP Top 25, but only one of them may be left there by the end of September.

Week 4 Top 25 Schedule and Odds

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    LINCOLN, NEBRASKA - SEPTEMBER 14: Dylan Raiola #15 of the Nebraska Cornhuskers passes against the Northern Iowa Panthers during the first quarter at Memorial Stadium on September 14, 2024 in Lincoln, Nebraska. (Photo by Steven Branscombe/Getty Images)
    Steven Branscombe/Getty Images

    Friday, September 21

    No. 24 Illinois at No. 22 Nebraska (-9) (8 p.m. ET, Fox)

    Saturday, September 22

    Marshall at No. 3 Ohio State (-39.5) (Noon ET, Fox)

    NC State at No. 21 Clemson (-17) (Noon ET, ABC)

    Arkansas State at No. 20 Iowa State (-21) (2 p.m. ET, ESPN+)

    Kent State at No. 10 Penn State (-49) (3:30 p.m. ET, BTN)

    No. 11 USC (-5.5) at No. 18 Michigan (3:30 p.m. ET, CBS)

    Miami (Ohio) at No. 17 Notre Dame (-27) (3:30 p.m. ET, NBC)

    Georgia Tech at No. 19 Louisville (-10.5) (3:30 p.m. ET, ESPN2)

    Buffalo at No. 23 Northern Illinois (-14) (3:30 p.m. ET, ESPN+)

    UCLA at No. 16 LSU (-22.5) (3:40 p.m. ET, ABC)

    No. 12 Utah at No. 14 Oklahoma State (-3) (4 p.m. ET, Fox)

    Vanderbilt at No. 7 Missouri (-21) (4:15 p.m. ET, SEC Network)

    No. 8 Miami (-17) at South Florida (7 p.m. ET, ESPN)

    No. 6 Tennessee (-7.5) at No. 15 Oklahoma (7:30 p.m. ET, ABC)

    Bowling Green at No. 25 Texas A&M (-23.5) (7:30 p.m. ET, ESPN+)

    Georgia Southern at No. 5 Ole Miss (-35.5) (7:45 p.m. ET, SEC Network)

    UL-Monroe at No. 1 Texas (-45) (8 p.m. ET, ESPN+)

    No. 13 Kansas State (-7.5) at BYU (10:30 p.m. ET, ESPN)

No. 6 Tennessee (-7.5) at No. 15 Oklahoma

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    KNOXVILLE, TN - SEPTEMBER 14: Tennessee Volunteers quarterback Nico Iamaleava (8) scrambles out of the pocket during the college football game between the Tennessee Volunteers and the Kent State Golden Flashes on September 14, 2024, at Neyland Stadium in Knoxville, TN. (Photo by Bryan Lynn/Icon Sportswire via Getty Images)
    Bryan Lynn/Icon Sportswire via Getty Images

    Nico Iamaleava has been one of the best performers in all of college football through three weeks.

    The Tennessee quarterback is a star in the making and he should add to his growing legend in Norman on Saturday night.

    Iamaleava is a far more explosive quarterback than Oklahoma's Jackson Arnold, who entered the season in the same category as the Vols signal-caller as players potentially ready to take the next step into stardom.

    Iamaleava has 200 more passing yards than Arnold and he's led the Vols offense to three straight 50-point performances.

    Oklahoma scored 50 points in the last two weeks after putting up 51 on the Temple Owls in Week 1.

    The Sooners' struggles at home with the Houston Cougars and Tulane Green Wave are concerning because a few bad drives against Tennessee could put them in a multi-score hole.

    Tennessee has not waited around for anyone, and while Iamaleava received a lot of the praise, the defense, led by potential No. 1 NFL Draft pick James Pearce, has given up 13 points in three games.

    Oklahoma should win a handful of SEC games, but it's hard to see a path to it sticking within a touchdown of the Vols, even at home.

No. 12 Utah at No. 14 Oklahoma State (-3)

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    STILLWATER, OK - AUGUST 31: Running back Ollie Gordon II #0 of the Oklahoma State Cowboys powers his way into the end zone for a 12-yard touchdown past safety Tucker Large #1 of the South Dakota State Jackrabbits in the second quarter at Boone Pickens Stadium on August 31, 2024 in Stillwater, Oklahoma. Oklahoma State leads 17-6 after the first half. (Photo by Brian Bahr/Getty Images)
    Brian Bahr/Getty Images

    The Utah-Oklahoma State game has an injury cloud hovering over it.

    Utah quarterback Cam Rising has unfortunately been one of the more injury-prone players in the FBS in recent years and he sat out the Week 3 win over the Utah State Aggies with a hand injury.

    Rising is expected to play in Stillwater on Saturday, but it is concerning that Utah's most important player will not be at 100 percent.

    Oklahoma State scored at least 39 points in each of its first three games behind one of the most experienced offenses in the country.

    Running back Ollie Gordon is the star of the show, but veteran quarterback Alan Bowman has played well too with 967 passing yards.

    OK State is in a far more cohesive rhythm on offense going into Saturday, and that combined with the home-field advantage in Stillwater, could give the Cowboys the edge at the start of an important two weeks.

    Mike Gundy's team visits the Kansas State Wildcats in Week 5, and if it wins both games, it will be the Big 12's favorite to reach the College Football Playoff as conference champion.

No. 11 USC at No. 18 Michigan (+5.5)

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    ANN ARBOR, MI - SEPTEMBER 14:  Michigan Wolverines running back Kalel Mullings (20) runs with the ball during the second quarter of a non-conference college football game between the Arkansas State Red Wolves and the Michigan Wolverines on September 14, 2024 at Michigan Stadium in Ann Arbor, Michigan.  (Photo by Scott W. Grau/Icon Sportswire via Getty Images)
    Scott W. Grau/Icon Sportswire via Getty Images

    It's still hard to believe the USC Trojans and Michigan Wolverines reside in the same conference.

    That reality hits home on Saturday with USC's trip to Michigan Stadium.

    Michigan needs a win more than USC so it can prove it can compete with the best programs in the country and that the loss to Texas was a one-off result.

    The Wolverines have a clear identity of running the ball and playing tough defense. That could pose a problem to Miller Moss in his first true road start of the campaign.

    USC looks like it could play a grind-it-out style game with its new-look defense that allowed 20 points in two weeks.

    However, Michigan has perfected winning that type of game in recent years, and its defense could rattle Moss into some turnovers.

    The Wolverines need much better quarterback play out of Davis Warren to pull off the upset, but if they minimize his high-risk throws and run the ball effectively, they can creep back up the rankings in Week 5.

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